Open AccessPossible Nutrition-Related Mechanisms of Metabolic Management in Cancer Treatment
Author(s) -
Adeleh Khodabakhshi,
Maryam Mahmoudi,
Hassan Mehrad Majd,
Sayed Hossein Davoodi
Publication year - 2021
Publication title -
international journal of cancer management
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.251
H-Index - 19
eISSN - 2538-4422
pISSN - 2538-497X
DOI - 10.5812/ijcm.107678
Subject(s) - ketogenic diet , calorie restriction , glutamine , cancer , context (archaeology) , oxidative phosphorylation , cancer cell , ketone bodies , bioinformatics , biology , medicine , pharmacology , cancer research , biochemistry , metabolism , neuroscience , amino acid , paleontology , epilepsy
Context: Somatic mutation theory has been considered as a potential cause for cancer. However, major inconsistencies with the gene theory have necessitated serious reconsideration of this assumption. According to these inconsistencies, cancer may be considered as a metabolic disorder. According to the mitochondrial metabolic theory, substrate-level phosphorylation has been suggested to be superior to oxidative phosphorylation in cancer cells. Cancer metabolic therapies such as ketogenic diets (KD) and limitation in glutamine and calorie can be beneficial and are in line with this theory. In this study, we have reviewed the potential effects of KD as well as glutamine and calorie restriction in various types/stages of cancer with a focus on possible mechanisms. Evidence Acquisition: A comprehensive electronic search of different databases was performed using “cancer”, “ketogenic diet”, and “metabolic” as the main keywords. A comprehensive electronic search of different databases was performed using “cancer”, “ketogenic diet”, and “metabolic” as the main keywords. Results: Emerging evidence has indicated that KD can affect tumor cells by reducing glucose availability and simultaneous elevation of ketone bodies as non-fermentable metabolic fuels. KD has been suggested to be more effective as a non-toxic therapeutic measure in combination with glutamine targeting agents, chloroquine for lysosomal targeting, hyperbaric oxygen therapy, and calorie restriction. Conclusions: This metabolic approach can be considered as a promising non-toxic strategy for cancer management.