Open AccessPost Intensity-Modulated Radiation Therapy Urinary Function for Prostate Cancer; A Prospective Study
Author(s) -
Farzad Allameh,
Amirhossein Rahavian,
Bahram Mofid,
Samira Azghandi,
Amir Reza Abedi,
Abbas Basiri,
Saeed Montazeri
Publication year - 2020
Publication title -
international journal of cancer management
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.251
H-Index - 19
eISSN - 2538-4422
pISSN - 2538-497X
DOI - 10.5812/ijcm.102170
Subject(s) - medicine , prostate cancer , genitourinary system , radiation therapy , prostate , prospective cohort study , international prostate symptom score , urinary system , urology , cancer , lower urinary tract symptoms
Background: At present, there is a lack of evidence concerning urinary complications caused by intensity-modulated radiation therapy (IMRT) used for the management of prostate cancer (PCa). Objectives: This study aimed at identifying the nature and severity of post-IMRT urinary symptoms in patients with PCa. Methods: This prospective study was performed with consecutive patients, who had clinically localized PCa (cT1c-cT2c) and had undergone IMRT treatment from 2016 to 2019. At 1, 6, and 12 months of follow-up, medical history, physical information, prostate-specific antigen values, International Prostate Symptom Score (IPSS), medication use, Radiation Therapy Oncology Group (RTOG), acute and late toxicity, and Q max were collected. Results: A total of 127 patients with a mean age of 71.04 ± 7.1 years received IMRT and underwent 12 months of follow-up. The mean IPSSs at baseline versus those at 1, 6, and 12 months after IMRT was 14.5 ± 6.8 versus 13.3 ± 6.1, 12.3 ± 5.3, and 10.4 ± 4.2, respectively (P < 0.000). The mean prostate volume was 38.2 ± 12.1 cc. At the last follow-up, 31 patients (24.4%) took genitourinary (GU) medications. Conclusions: This study showed that the majority of GU side effects caused by primary IMRT for PCa treatment are transient. Treatment triggered an acute increase in obstructive urinary symptoms, which peaked during the first month after IMRT. In most patients, in the course of 6 months, symptoms returned to baseline.