Open AccessLong-term Outcome in Children with Wilms’ Tumor; Experience of a Single Center for Two Decades
Author(s) -
Leily Mohajerzadeh,
Ahmad Khaleghnejad,
Mohsen Rouzrokh,
Shahin Shamsian,
Javad Ghoroubi,
Omid Amonollahi,
Gholamreza Ebrahimisaraj,
Arameh Abbasianchavari
Publication year - 2021
Publication title -
international journal of cancer management
Language(s) - English
Resource type - Journals
eISSN - 2538-4422
pISSN - 2538-497X
DOI - 10.5812/ijcm.102113
Subject(s) - wilms' tumor , stage (stratigraphy) , medicine , histopathology , single center , pediatrics , cancer , subspecialty , surgery , pathology , paleontology , biology
Background: Wilms’ tumor (nephroblastoma) is the major renal cancer in children. Objectives: The aim of this study was to assess the individuality of Wilms’ tumor and the consequences of management attained in our referral subspecialty center. Methods: In this study, we composed the data of children with Wilms’ tumor in 2 decades; 55 cases between 1992 and 2002 and 49 patients between 2006 and 2016 were diagnosed with Wilms’ tumor. Demographic characters, a form of presentation, tumor stage, related underlying disease, histopathology consequences, type of management, and the survival rates were assessed. Results: In the first decade, 24 patients were females and 31 were males (M/F = 1.2); in the other groups, 30 were females and 19 were males (M/F = 0.61). The mean age was 45.2 months at the time of diagnosis for the first group and the mean age was 36 months for the other group. In the first decade, the surgical stage after the operation was as follows: stage I (32.7%), stage II (16.36%), stage III (38.1%), stage IV (9%), and stage V (1.8%) who did not operate. In second decade, 49 patients were as follows: stage I (14.3%), stage II (40.8%), stage III (24.5%), stage IV (10.2%), and stage V (10.2%). In 54.5% of the first group, histology was favorable, and in 43.6% of the first group, histology was unfavorable; in the second group, 95.4% were the favorable type. The patients were managed based on protocols of the National Wilms’ Tumor Study. In the first decade, relapse-free was 71% and 4-year survival rates were estimated at 86%, and in the second decade, pulmonary metastasis was observed at 28.6%, liver metastasis in 2.3%, recurrence in 5%, and 4-year survival rates were estimated at 90%. Conclusions: This study demonstrated development in the management of children with Wilms’ tumor in recent 20 years, with comparable relapse-free and survival rates to the National Wilms’ Tumor study. But with more adjustment in treatment protocols, the superior outcome will be attainable.