Open AccessAST and HBeAg Level Can Help to Distinguish Non-Minimal Liver Inflammation in Persistently Normal Alanine Aminotransferase of Chronic HBV Infection
Author(s) -
Zhigang Lu,
Ming Hui Li,
Wei Yi,
Yao Lu,
Shuling Wu,
Hongxiao Hao,
Yumei Gao,
Huihui Lu,
Qiqi Chen,
Ge Shen,
Ming Chang,
Leiping Hu,
Ruyu Liu,
Lei Sun,
Gang Wu,
Yao Xie
Publication year - 2020
Publication title -
hepatitis monthly
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.264
H-Index - 37
eISSN - 1735-3408
pISSN - 1735-143X
DOI - 10.5812/hepatmon.99580
Subject(s) - medicine , hbeag , gastroenterology , hbsag , inflammation , alanine aminotransferase , liver biopsy , alanine transaminase , chronic hepatitis , immunology , hepatitis b virus , biopsy , virus
Objectives: The current study aimed to investigate the characteristics of HBV serum markers (HBsAg, HBeAg), biochemical indicators, HBV DNA, and the age to distinguish minimal from non-minimal liver histological inflammation group in HBeAg-positive chronic HBV-infected patients with ALT≤ 1ULN (40U/L). Methods: The HBeAg-positive patients with treatment-naïve hospitalized at Ditan hospital from January 2008 to January 2017 are investigated. Patients were separated into two groups of minimal and non-minimal (mild and moderate) histological inflammation group by liver biopsy specimens. Data were analyzed using the SPSS package. Results: There were both positive (age, ALT, and AST) and negative correlation factors (serum HBsAg, HBeAg, or HBV DNA quantitation) to the liver inflammation grades. Multivariate regression analysis indicated that HBeAg (P 28 U/L) were the independent influential factors of predicting non-minimal liver inflammation with ALT ≤ 1 ULN (40U/L).