Open AccessThe Prevalence of Viruses in the Cerebrospinal Fluid of Children with Aseptic Meningitis in Shiraz, Iran
Author(s) -
Anahita Sanaei Dashti,
Masoomeh Khalifeh,
Elham Yousefifar,
Mohammad Rahim Kadivar,
Marzieh Jamalidoust,
Mandamayandeh,
Babak Abdinia
Publication year - 2020
Publication title -
archives of clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.22
H-Index - 14
ISSN - 2345-2641
DOI - 10.5812/archcid.100850
Subject(s) - aseptic meningitis , viral meningitis , enterovirus , medicine , measles , echovirus , rubella , meningitis , mumps virus , pediatrics , vomiting , virology , enterovirus 71 , immunology , virus , vaccination , bacterial meningitis
Objectives: The current study aimed to evaluate the causative agents of viral meningitis through real-time PCR among children with aseptic meningitis. Methods: Children aged 1 month to 16 years with suspected viral meningitis were enrolled in this study (March 2014-February 2015). Cerebrospinal fluid samples were analyzed by real-time PCR for detection of enterovirus, mumps, measles, adenovirus, EBV, CMV, VZV, hhv 6, and rubella viruses. Demographic information, laboratory data, and clinical presentations of patients were also collected. Results: Of 56 patients suspected to viral meningitis, 21 (38.9 %) had a positive PCR result. Enterovirus (42.85%) and mumps (38.1%) were the most prevalent viruses, and VZV and measles were not detected. Three children were coinfected with enterovirus/hhv6, enterovirus/EBV, and mump/adenovirus. Fever, headache, and nausea/vomiting were the most common symptoms in children. The rates of symptoms were not statistically significant among children with positive and negative PCR tests. Conclusions: In the present study Enterovirus and mumps viruses were the most common causes of viral meningitis in children. PCR, as a rapid test for the diagnosis of viral meningitis, can be used to decrease hospitalization length.