Open AccessThe Effect of Elevated Homocysteine Levels on Atherosclerosis in Patients with Peritoneal Dialysis
Author(s) -
Fatih Şahpaz
Publication year - 2016
Publication title -
journal of clinical and experimental investigations
Language(s) - English
Resource type - Journals
eISSN - 1309-6621
pISSN - 1309-8578
DOI - 10.5799/ahinjs.01.2016.01.0569
Subject(s) - medicine , homocysteine , continuous ambulatory peritoneal dialysis , arterial stiffness , peritoneal dialysis , triglyceride , gastroenterology , hyperlipidemia , cholesterol , intima media thickness , inflammation , arteriosclerosis , cardiology , endocrinology , carotid arteries , diabetes mellitus , blood pressure
Objective: Cardiovascular disease is an important cause of morbidity and mortality in patients with renal failure. Patients with chronic renal failure are significantly susceptible to atherosclerosis. In the present study, we aimed to investigate the effect of elevated homocysteine on atherosclerosis and inflammation in continuos ambulatory peritoneal dialysis (CAPD) patients.\udMethods: 56 patients undergoing CAPD and 27 healthy subjects was enrolled in the study. All patients total cholesterol, triglyceride, LDL cholesterol, HDL cholesterol, hs-CRP, homocysteine, intima-media thickness, arterial stiffness values were measured and statistically analyzed.\udResults: It is determined that the levels of total cholesterol, triglyceride, LDL cholesterol, HDL cholesterol, homocysteine, intima-media thickness, arterial stiffness and hs-CRP was higher in patients compared to the control group (in order; p=0.03, p=0.0006, p=0.02).\udConclusion: Carotid intima-media thickness being increased because of increased levels of homocysteine and inflammation in CAPD patients. Therefore, in case of atherosclerosis, hyperlipidemia and inflammation more aggressive treatment protocol should be considered. Patients with elevated plasma homocysteine concentrations should be treated. J Clin Exp Invest 2016; 7 (1): 47-5