Open AccessAGRANULOCITOSE RELACIONADA À OXACILINA. RELATO DE CASO
Author(s) -
Kleber Jordão Souza,
Juliana Mussolini Celestino de Oliveira,
Rodolfo Dias Gomes,
Rebeca Carvalho Bressa,
José Antônio Nascimento Bressa
Publication year - 2013
Publication title -
colloquium vitae
Language(s) - English
Resource type - Journals
ISSN - 1984-6436
DOI - 10.5747/cv.2013.v005.n1.v077
Subject(s) - medicine , asymptomatic , anesthesia , white blood cell , adverse effect , blood count , lumbar puncture , surgery , cerebrospinal fluid
Agranulocytosis is characterized by a reduction of neutrophils in peripheral blood, and about two thirds of cases occur due to adverse reactions to drugs. We report a case of a Caucasian man that in prolonged use of oxacillin due a septic spondylodiscytis developed agranulocytosis. Male patient, 70 years-old, was admitted to the emergency room complaining of pain in the lumbar region for 30 days. Diagnosed with septic spondylodiscytis on plateaus vertebral level L5-S1. He was treated empirically with oxacillin. Antibiotic therapy continued until the twenty-ninth day. Blood count presented: leukocyte counts of 0.870/mm³ (without differential count). After suspension of oxacillin, white blood cell count was not reestablished, was administered granulocyte colony-stimulating factor Filgastrima at a dose of 0.5MU/Kg day (5g/Kg/day) for three days. This report aims to highlight that the use of intravenous oxacillin for prolonged periods may induce agranulocytosis, and to emphasize that even asymptomatic patient monitoring should be performed.