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Assessing angiotensin‐converting enzyme ( ACE ) protein is more appropriate than ACE activity when investigating sarcoidosis
Author(s) -
Pretorius Carel J,
Ungerer Jacobus PJ
Publication year - 2020
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/mja2.50620
Subject(s) - medicine , sarcoidosis , angiotensin converting enzyme , ace inhibitor , diabetes mellitus , population , blood pressure , endocrinology , environmental health
Elevated serum angiotensinconverting enzyme (ACE) activity, a biomarker for epithelioid granuloma, has a supportive role in the diagnosis and management of sarcoidosis,1 although in populationbased studies its diagnostic usefulness is modest, with positive and negative predictive values of 25.4% and 89.9% respectively.2 Further, elevated ACE activity is nonspecific; it is also found in people with tuberculous and other infectious granulomata, liver disease, lymphoma, diabetes, or hyperthyroidism, and also as a benign familial condition. However, elevated ACE activity can facilitate some clinical decisions, including the diagnosis of Löfgren syndrome or adults with uveitis.1,3