Prolonged tumour growth after treatment of infantile haemangioma with propranolol

A. Patient 1 at 13 days of age, before treatment. B. At nfantile haemangioma is the most common tumour of infancy, sometimes requiring treatment because of the risk of functional 10 months, almost complete clearing after treatment with oral propranolol, together with brief oral prednisolone and pulsed dye laser therapy. C. At 2 years, redevelopment of surface vessels despite continuing propranolol (3 mg/kg/ day). D. At 5.5 years, progressive thickening of haemangioma in the lip and several clumps, despite treatment with propranolol, laser, and topical timolol and sirolimus