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Severe drug‐induced hypersensitivity syndrome with a shared HLA‐B allele
Author(s) -
Harding Damian J,
Subramaniam Kavitha,
MacQuillan Gerry,
Davis Joshua,
Nolan David
Publication year - 2012
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/mja12.10477
Subject(s) - medicine , hepatology
We describe the first reported cases of phenytoin-related drug-induced hypersensitivity syndrome in unrelated Indigenous Australians with the same HLA-B*56:02 allele. These patients shared common clinical and pathological features, and all three were found to have the otherwise rare HLA-B allele, which might represent a novel genetic susceptibility factor for this syndrome.