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Thrombolysis for acute stroke in Australia: outcomes from the Safe Implementation of Thrombolysis in Stroke registry (2002–2008)
Author(s) -
Simpson Marion A,
Dewey Helen M,
Churilov Leonid,
Ahmed Niaz,
Bladin Christopher F,
Schultz David,
Markus Romesh,
Sturm Jonathan W,
Levi Christopher R,
Blacker David J,
Jannes Jim,
Lindley Richard I,
Parsons Mark W
Publication year - 2010
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.2010.tb03996.x
Subject(s) - thrombolysis , medicine , stroke (engine) , odds ratio , cohort , intracerebral hemorrhage , modified rankin scale , tissue plasminogen activator , cohort study , odds , acute stroke , observational study , fibrinolytic agent , physical therapy , emergency medicine , logistic regression , ischemic stroke , subarachnoid hemorrhage , myocardial infarction , mechanical engineering , engineering , ischemia
Objective: To report Australian outcomes from the Safe Implementation of Thrombolysis in Stroke International Stroke Thrombolysis Register (SITS‐ISTR). Design: Observational study using data collected prospectively from December 2002 to December 2008. Setting: Centres administering thrombolysis for acute stroke in Australia and worldwide. Patients: All patients treated with recombinant tissue plasminogen activator for acute stroke in participating centres, regardless of stroke severity, time of treatment and other clinical factors. Intervention: Thrombolysis for acute stroke, administered according to local protocol. Main outcome measures: Functional outcome as 3‐month modified Rankin score (mRS), and frequency of symptomatic intracerebral haemorrhage (ICH). Results: During the study period, a total of 32 countries participated, and confirmed baseline data were available for 581 Australian patients and 20 953 patients in the rest of the world. Australian patients were older (median age, 73 v 69 years; P < 0.001), were less independent before stroke (premorbid mRS of 0–1, 87.5% v 91.2%; P < 0.005), and had more comorbidities and more severe strokes. Comparing the Australian cohort with the rest of the world, the odds ratio of 3‐month mRS of 0–2 was 0.98 (95% CI, 0.88–1.08; P = 0.63), the odds ratio of symptomatic ICH was 0.98 (95% CI, 0.83–1.16; P = 0.85 [by the definition used by the National Institute of Neurological Disorders]) and the odds ratio of death was 1.04 (95% CI, 0.91–1.19; P = 0.54). Good outcome in the Australian cohort was predicted by younger age, presence of hyperlipidaemia, lower premorbid mRS, absence of infarct on early brain imaging, less severe stroke, and lower baseline blood glucose level. Conclusion: Clinical outcomes after thrombolysis in Australia were similar to those worldwide.