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Guidelines for the management of paracetamol poisoning in Australia and New Zealand — explanation and elaboration
Author(s) -
Daly Frank F S,
Fountain John S,
Murray Lindsay,
Graudins Andis,
Buckley Nicholas A
Publication year - 2008
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.2008.tb01625.x
Subject(s) - medicine , elaboration , accidental , intensive care medicine , medical emergency , philosophy , physics , humanities , acoustics
Paracetamol is involved in a large proportion of accidental paediatric exposures and deliberate self‐poisoning cases, although subsequent hepatic failure and death are both uncommon outcomes. The optimal management of most patients with paracetamol overdose is usually straightforward. However, several differing nomograms and varying recommendations regarding potential risk factors for hepatic injury introduce complexity. In order to reconcile management advice with current Australasian clinical toxicology practice, revised guidelines have been developed by a panel of clinical toxicologists consulting to the poisons information centres in Australia and New Zealand using a workshop and consultative process. This article summarises the rationale for the recommendations made in these new guidelines.