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Tumour necrosis factor α inhibitors: screening for tuberculosis infection in inflammatory bowel disease
Author(s) -
Gupta Arun,
Street Alan C,
Macrae Finlay A
Publication year - 2008
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.2008.tb01565.x
Subject(s) - medicine , latent tuberculosis , infliximab , tuberculosis , rheumatoid arthritis , immunology , inflammatory bowel disease , tuberculin , ulcerative colitis , tumor necrosis factor alpha , disease , mycobacterium tuberculosis , pathology
Tumour necrosis factor (TNF) α inhibitors such as infliximab are becoming more widely used for the treatment of selected patients with Crohn's disease, rheumatoid arthritis, and other inflammatory disorders. TNFα inhibitors increase the risk of serious infections, including tuberculosis. Screening for and treatment of latent tuberculosis infection before infliximab therapy reduces the risk of developing active tuberculosis. New blood tests that measure interferon γ production are an alternative to traditional tuberculin skin testing and offer some significant advantages over skin testing for screening of latent tuberculosis infection.