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Glucose tolerance abnormalities in Australian women with polycystic ovary syndrome
Author(s) -
Dabadghao Preeti,
Roberts Bronwen J,
Wang Jim,
Davies Michael J,
Norman Robert J
Publication year - 2007
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.2007.tb01273.x
Subject(s) - polycystic ovary , impaired glucose tolerance , medicine , diabetes mellitus , odds ratio , family history , body mass index , abdominal obesity , impaired fasting glucose , obesity , waist , metabolic syndrome , endocrinology , glucose tolerance test , type 2 diabetes , obstetrics , insulin resistance
Objectives: To determine the prevalence of glucose tolerance abnormalities and to identify associated risk factors in women with polycystic ovary syndrome (PCOS) attending a reproductive endocrinology clinic. Design: Retrospective chart review. Participants and setting: 372 women with confirmed PCOS attending a reproductive endocrinology clinic at Adelaide University's Research Centre for Reproductive Health. Main outcome measures: Prevalence of glucose tolerance abnormalities and association of such abnormalities with potential risk factors. Results: 4.0% (15 women) had diabetes mellitus, 15.6% (58) had impaired glucose tolerance and 80.4% (299) had normal glucose tolerance. There was a significant trend towards increasing prevalence of diabetes with increasing age (odds ratio [OR], 0.60; P = 0.0085). The prevalence of abnormal glucose tolerance (diabetes and impaired glucose tolerance together) was significantly higher with higher waist circumference (OR, 2.9; P = 0.05), higher body mass index (OR, 8.02; P = 0.0253), a family history of diabetes (OR, 1.56; P = 0.0192) and the presence of metabolic syndrome (OR, 5.62; P < 0.001). Conclusion: The prevalence of diabetes and impaired glucose tolerance is high in women with PCOS, especially in older women and those with abdominal obesity and a family history of diabetes.