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Amisulpride deliberate self‐poisoning causing severe cardiac toxicity including QT prolongation and torsades de pointes
Author(s) -
Isbister Geoffrey K,
Murray Lindsay,
John Sally,
Hackett L Peter,
Haider Tedo,
OˈMullane Phebe,
Gosselin Sophie,
Daly Frank
Publication year - 2006
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.2006.tb00272.x
Subject(s) - torsades de pointes , officer , medicine , family medicine , psychology , qt interval , political science , law
Although clinical trials of the antipsychotic amisulpride revealed no cardiac adverse effects, four patients with severe cardiac toxicity after overdose were reported to Australian poisons information centres in 2004-2005. All four had QT prolongation over 500 ms, two had rate-dependent bundle branch block, two developed torsades de pointes, and one died after cardiac arrest. Pending further studies, we recommend electrocardiogram assessment until at least 16 h after amisulpride overdose and, if QT interval is prolonged, cardiac monitoring until the patient is clinically well and conduction intervals are normal.