Microscopic colitis associated with exposure to lansoprazole

MJA • Volume 184 Number 4 • 20 Feb The Medical Journal of Australia ISSN: 0025-729X 20 February 2006 184 4 185186 ©The Medical Journal of Australia 2006 www.mja.com.au LessonS From Practice may be a spectrum of the same disease. This is y our report of three lansoprazole-associated cases, in showed lymphocytic colitis, one showed collagenous ne showed transitional features of both on histopathomination. The inflammatory infiltrate and collagen in these cases was less severe than that seen in typical phocytic and collagenous colitis, probably because of icr cau pa M oscopic colitis is increasingly recognised as a major se of persistent diarrhoea. It is an idiopathic clinicothological syndrome of chronic watery non-bloody diarrhoea associated with a normal appearance on colonoscopy and specific histopathological changes of lymphocytic and/or collagenous colitis. There is a high rate of spontaneous resolution and relapse in microscopic colitis, and effective treatment is limited. The pathogenesis of microscopic colitis is poorly understood and is thought to be related to a poorly regulated epithelial immune response to luminal or epithelial antigens including bile acids, toxins, or infectious agents. Microscopic colitis has been associated with autoimmune diseases and with exposure to medications, predominantly non-steroidal anti-inflammatory drugs, and, rarely, salicylates, simvastatin, ticlopidine, ranitidine, carbamazepine, Cyclo 3 Fort (a combination of Ruscus aculeatus extract, hesperidin methylchalcone, and ascorbic acid), flutamide, gold salts, and, recently, lansoprazole. Lymphocytic and collagenous colitis are probably aetiologically related, and supported b which one colitis and o logical exa deposition cases of lym Clinical record