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Gudair (OJD) vaccine self‐inoculation: a case for early debridement
Author(s) -
Richardson Graeme D,
Links Ian I,
Windsor Peter A
Publication year - 2005
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.2005.tb06966.x
Subject(s) - windsor , medicine , library science , veterinary medicine , biology , computer science , ecology
The Medical Journal of Australia ISSN: 0025729X 1 August 2005 183 3 151-152 ©The Medical Journal of Australia 2005 www.mja.com.au Lessons from Practice (CZ Veterinaria, Porriño, Spain), which is distribu Animal Health. (The Gudair vaccine has been availab since late 1999 for experimental use in about 50 approv research work led to registration of the product in April Vaccination of sheep against OJD is now widesprea over 7 million vaccinations have been performed — p central and southern tablelands and south-west slopes vin sh pa O e Johne’s disease (OJD) is a chronic wasting disease of eep caused by the “S” strain of Mycobacterium avium subsp. ratuberculosis. It has spread widely through Australian sheep flocks, causing significant economic loss since it was first detected in New South Wales in 1980. A national vaccination program to control OJD is currently in progress using Gudair vaccine 1 ted by Pfizer le in Australia ed flocks. This 2002.) d in Australia: rimarily in the of New South Wales, across Victoria and on Kangaroo Island (SA), and to a lesser extent in the northern tablelands and western areas of NSW, mainland South Australia, Tasmania and Western Australia. Each 1mL dose of Gudair contains killed (heat-inactivated) Mycobacterium paratuberculosis organisms and mineral oil, with thiomersal as a preservative. The oil forms a depot at the injection site to act as a potent adjuvant, stimulating a cell-mediated immune response to the mycobacteria. In humans, accidental injection or exposure of the skin surface or mucous membrane may cause a severe local reaction and, uncommonly, a systemic reaction. Despite education of vaccinators, there have recently been seven documented cases of accidental self-inoculation in Australia resulting in prolonged morbidity.2,3 Wider use of the vaccine has increased the risk of self-inoculation injuries. There is a need to improve safety for farmers during vaccination and to bring the potential for serious complications of self-inoculation to the attention of doctors in rural areas. Accidental self-injection may occur because of inadequate animal restraint, poor inoculation technique or carelessness, facilitated by hanging the automatic vaccinating syringe from the neck (Box 3) or shoulder. Clinical record