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Inflammation and remodelling in the ageing airway
Author(s) -
Wilson John W
Publication year - 2005
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.2005.tb06915.x
Subject(s) - asthma , medicine , airway , ageing , inflammation , airway obstruction , disease , vascular remodelling in the embryo , immunology , surgery
What we need to knowWhat changes occur in atopic and non‐atopic airway inflammation in asthma with increasing age? What is the relationship between wound healing and airway remodelling in older subjects? What is the response to anti‐inflammatory therapy in older subjects? What is the basis of the “overlap syndrome” with chronic obstructive pulmonary disease in older people with asthma, in whom smoking contributes to airway disease?What we need to doIdentify the contribution of immunological mechanisms to asthma in ageing. Determine the extent to which airway remodelling plays a role in airflow obstruction in older people, specifically reversible components. Reduce the impact of smoking in young people with asthma.