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Metformin therapy and diabetes in pregnancy
Author(s) -
Simmons David,
Walters Barry N J,
Rowan Janet A,
McIntyre H David
Publication year - 2004
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.2004.tb06024.x
Subject(s) - metformin , medicine , pregnancy , gestational diabetes , diabetes mellitus , offspring , insulin resistance , obstetrics , clinical trial , insulin , pediatrics , gestation , endocrinology , genetics , biology
No adverse pregnancy outcomes with metformin use have been reported, except in one unmatched study. Otherwise, the studies are small and non‐randomised, with the exception of one prospective, randomised controlled trial, currently under way, comparing metformin with insulin in women with gestational diabetes mellitus (the MiG trial). No long‐term follow‐up data for offspring of mothers receiving metformin have been published. Any woman with diabetes should be as close to euglycaemia as possible before pregnancy. In some circumstances (eg, severe insulin resistance), metformin therapy during pregnancy may be warranted. When metformin treatment is being considered, the individual risks and benefits need to be discussed with the patient so that an appropriate decision can be reached.