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Lyodura use and the risk of iatrogenic Creutzfeldt–Jakob disease in Australia
Author(s) -
Brooke Fiona J,
Boyd Alison,
Klug Genevieve M,
Masters Colin L,
Collins Steven J
Publication year - 2004
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.2004.tb05863.x
Subject(s) - medicine , disease , incidence (geometry) , cadaveric spasm , creutzfeldt jakob syndrome , transmission (telecommunications) , pediatrics , surgery , pathology , prion protein , physics , electrical engineering , optics , engineering
Although infectiousness is a feature of Creutzfeldt–Jakob disease (CJD), only a small proportion of cases are linked to transmission through healthcare provision. As of January 2003, over 120 cases of CJD associated with use of human cadaveric dura mater had been recognised worldwide; almost all were associated with the commercial product Lyodura. Most cases (97) have occurred in Japan, giving an overall risk estimate of around 1 per 2268 patients treated with Lyodura (0.04%) in that country. In Australia, five cases of CJD have so far been linked to Lyodura, but, given the protracted tails of previous epidemics of transmissible spongiform encephalopathies, further cases are possible. Results of surveys of Lyodura use in Australia are incomplete, but information from the manufacturer suggests that 2208–2478 sheets of Lyodura may have been used here. This use translates to a relatively high incidence of Lyodura‐associated CJD, with current overall rates appearing around five times higher than those reported in Japan; reasons for this difference are unclear.