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Adult human neural stem cells for cell‐replacement therapies in the central nervous system
Author(s) -
Galvin Kerry A,
Jones D Gareth
Publication year - 2002
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.2002.tb04791.x
Subject(s) - neural stem cell , central nervous system , transplantation , neuroscience , biology , embryonic stem cell , spinal cord injury , stem cell , neural cell , nervous system , spinal cord , cell , medicine , microbiology and biotechnology , surgery , biochemistry , genetics , gene
Human neural stem cells (HNSCs) can be isolated from both the developing and adult central nervous system (CNS). HNSCs can be successfully grown in culture, are self‐renewable, and can generate mature neuronal and glial progeny. Embryonic HNSCs can be induced to differentiate into specific neuronal phenotypes. HNSCs successfully integrate into the host environment after transplantation into the developing or adult CNS. HNSCs transplanted into animal models of Parkinson's disease and spinal cord injury have induced functional recovery. The risks associated with stem cell transplantation trials are difficult to assess, but have not become overtly apparent throughout preclinical investigations. Major hurdles remain to be overcome before human clinical trials can be embarked upon.