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Sertraline treatment of interferon‐alfa‐induced depressive disorder
Author(s) -
Schramm T Mark,
Lawford Bruce R,
Cooksley W Graeme,
Macdonald Graeme A
Publication year - 2000
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.2000.tb125687.x
Subject(s) - sertraline , interferon alfa , medicine , serotonin reuptake inhibitor , depression (economics) , interferon , major depressive disorder , chronic hepatitis , reuptake inhibitor , hepatitis c , alpha interferon , psychiatry , gastroenterology , pharmacology , serotonin , immunology , antidepressant , virus , receptor , macroeconomics , amygdala , hippocampus , economics
Interferon alfa therapy for chronic hepatitis C infection is commonly associated with neuropsychiatric symptoms, including depression. These side effects may necessitate reduction or even cessation of interferon alfa, but there is little information regarding the management of this important problem. We report 10 cases of interferon‐alfa‐induced depressive disorder treated with the selective serotonin reuptake inhibitor sertraline. All patients obtained rapid symptom relief without the need for reduction or cessation of interferon alfa.