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Bacteraemia in febrile children presenting to a paediatric emergency department
Author(s) -
Haddon Rachael A,
Barnett Peter L J,
Grimwood Keith,
Hogg Geoffrey G
Publication year - 1999
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1999.tb127847.x
Subject(s) - medicine , emergency department , bacteremia , pediatrics , pneumonia , blood culture , respiratory tract infections , prospective cohort study , antibiotics , psychiatry , respiratory system , microbiology and biotechnology , biology
Objective To determine the prevalence of bacteraemia in young febrile children presenting to a paediatric emergency department. Design Prospective observational case study. Setting Emergency Department of the Royal Children's Hospital, Melbourne, between May 1996 and May 1997. Participants Patients aged 3‐36 months presenting to the Emergency Department with temperature 3= 39°C and without specific viral illnesses (varicella, croup or herpes gingivostomatitis). Outcome measures Bacteraemia (defined as presence of pathogenic bacteria in a blood culture), white blood cell count (WCC), McCarthy score, and final diagnosis based on clinical features and investigations. Results Bacteraemia was identified in 18 of 534 patients (3.4%). Pathogens isolated were Streptococcus pneumoniae (15), Neisseria meningitidis (2) and Klebsiella pneumoniae (1). Increased WCC counts (P<0.001) and brief duration of fever (P< 0.001) were associated with bacteraemia. Nevertheless, clinical features, including McCarthy scores, and high WCC counts (>20times10 9 /L) had <10% predictive accuracy for bacteraemia. Overall, final diagnoses in the 534 febrile children included non‐specific viral infections (25%), upper respiratory tract infections (24%), otitis media (10%), gastroenteritis (9%), pneumonia (7%), and urinary tract infection (5%). Conclusions Most urban Australian children aged 3‐36 months presenting to a paediatric emergency department with temperature 3= 39°C without a clinical focus have a viral infection. However, 3%‐4% have occult bacteraemia. Neither clinical features nor high WCC counts reliably identify these patients. As empiric antibiotics may contribute to increasing antibiotic resistance and have not been shown to prevent the rare complication of meningitis, we believe that close contact and regular review of these patients is preferable to empiric antibiotic therapy.