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Profound symptomatic bradycardia associated with combined mibefradil and B‐blocker therapy
Author(s) -
Rogers Ian R,
Prpic Ross
Publication year - 1998
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1998.tb126834.x
Subject(s) - mibefradil , bradycardia , medicine , beta blocker , cardiology , anesthesia , heart rate , heart failure , blood pressure , receptor , antagonist
We report two cases where the addition of mibefradil to long term {3‐blocker therapy in managing hypertension produced profound symptomatic bradycardia requiring cardiac pacing. Reports of a number of interactions between mibefradil and other cardioactive drugs have now led to its withdrawal from the market worldwide.