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Exacerbation of the inflammatory response to Mycobacterium tuberculosis after antiretroviral therapy
Author(s) -
John Mina,
French Martyn A H
Publication year - 1998
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1998.tb123372.x
Subject(s) - medicine , exacerbation , immunology , tuberculosis , mycobacterium tuberculosis , immunity , cellular immunity , inflammation , human immunodeficiency virus (hiv) , tuberculin , immune reconstitution inflammatory syndrome , antiretroviral therapy , immune system , viral load , pathology
A patient with HIV infection was successfully treated for pulmonary tuberculosis, but pulmonary inflammation and lymphadenitis worsened dramatically after subsequent combination antiretroviral therapy. As this relapse coincided with development of a strong delayed‐type hypersensitivity response to tuberculin and improved after treatment with the anti‐inflammatory agent oxpentifylline, it was probably caused by restoration of pathogen‐specific cellular immunity.