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Control of post‐transplant erythrocytosis by enalapril
Author(s) -
Wong Kai C,
Bandler Nicola S,
Kerr Peter G,
Atkins Robert C
Publication year - 1994
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1994.tb127600.x
Subject(s) - enalapril , erythropoietin , medicine , creatinine , urology , renal function , endocrinology , angiotensin converting enzyme , blood pressure
Objective To assess the erythropoietin response in patients with erythrocytosis after renal trans‐plantation who were treated with enalapril. Patients Fourteen patients with stable renal transplants (creatinine clearance, 74.4+ 24.6mL/min) and a packed cell volume of 51% or more over six months and who had no other cause for their erythrocytosis. Methods Patients were treated with enalapril for six months. Serum erythropoietin levels, creatinine clearance and packed cell volume were measured before and during the study; patients were reviewed each month. Results All patients had erythropoietin levels inappropriate for their packed cell volume. After six months' therapy with enalapril their mean erythropoietin concentration of 21.3± 5.0U/L fell to 7.4± 1.3U/L (P< 0.02) although the concentration increased in two patients. The mean packed cell volume fell from 52.7% ± 0.5% to 44.4% ± 1.0% ( P< 0.0001). There was no change in renal function. Conclusion Low‐dose enalapril controls post‐transplant erythrocytosis, at least in part, by lowering serum erythropoietin levels.