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Preventing acute gout when starting allopurinol therapy
Author(s) -
Kot Theresa V,
Day Richard O,
Brooks Peter M
Publication year - 1993
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1993.tb137784.x
Subject(s) - allopurinol , medicine , gout , colchicine , complication , hyperuricemia , peptic ulcer , gastrointestinal bleeding , surgery , intensive care medicine , gastroenterology , uric acid
Acute gout is a well known complication of the commencement of allopurinol therapy. Prophylaxis is needed for some months, even after serum urate levels have returned to normal. Colchicine is usually preferable to NSAIDs for this purpose, being cheaper, and better tolerated, especially in patients with peptic ulcer, gastrointestinal bleeding or dyspepsia or who are taking anticoagulants.