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Systemic absorption of glycine irrigation solution during endometrial ablation by transcervical endometrial resection
Author(s) -
Chui Po T,
Short Timothy G,
Leung Ares K L,
Tan Pet E,
Oh Teik E
Publication year - 1992
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1992.tb137432.x
Subject(s) - sodium , glycine , medicine , potassium , absorption (acoustics) , endometrial ablation , venous blood , urology , anesthesia , gastroenterology , surgery , chemistry , ablation , biochemistry , amino acid , materials science , organic chemistry , composite material
Objective To study systemic absorption of glycine irrigation solution and its consequences during transcervical endometrial resection (TCER). Design, setting, patients A prospective study of 20 consecutive female patients who underwent elective TCER in a teaching hospital. Method During the operation, patients were monitored with electrocardiography, automated oscillotonometry, pulse oximetry, capnography and a central venous pressure recorder. Plasma sodium and potassium levels were measured at 15‐minute intervals. Blood haemoglobin concentration, serum osmolality, and plasma sodium, potassium and glycine concentrations were measured before and after surgery. Results Plasma glycine concentration increased in all patients after TCER. The highest concentration recorded was 5575 μmol/L. The increase correlated only with the maximum intraoperative decrease in plasma sodium, which was 7 mmol/L in two patients Whose plasma glycine level increased by 3001 μmol/L and 5335 μmol/L. Conclusion Systemic absorption of glycine irrigation solution occurred in all patients during TCER. Serial measurement of plasma sodium was necessary to detect this complication. A decrease in plasma sodium level by 7 mmol/L or more during surgery would indicate fluid absorption that could cause severe hyperglycinaemia and other potential complications.