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Granulocyte colony stimulating factor in the management of chronic neutropenia
Author(s) -
Marlton Paula V,
Wright Susan J,
Taylor Kerry M
Publication year - 1992
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1992.tb121518.x
Subject(s) - neutropenia , medicine , granulocyte colony stimulating factor , sepsis , congenital neutropenia , granulocyte , leukopenia , surgery , intensive care medicine , chemotherapy
Objective To report two cases of chronic neutropenic states successfully treated with granulocyte colony stimulating factor (G‐CSF). Clinical features A 23‐year‐old man with severe congenital cyclic neutropenia causing lifelong recurrent infections and consequent debilitation presented with intractable infected leg ulcers. A 56‐year‐old man with acquired idiopathic neutropenia presented with severe perianal infection and sepsis. Intervention and outcome Both patients were successfully treated with recombinant G‐CSF. Conclusion G‐CSF is an agent with major clinical potential for the therapy of primary neutropenic states.