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Developments in surgical oncology — past, present and future trends
Author(s) -
Stephens Frederick O,
Marsden F William,
Storey David W,
Thompson John F,
McCarthy William H,
Renwick Stuart B,
Niesche Frederick W,
Bell Jenene M,
Watson Leanne D
Publication year - 1991
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1991.tb94042.x
Subject(s) - medicine , radiation therapy , chemotherapy , induction chemotherapy , head and neck , breast cancer , cancer , oncology , stage (stratigraphy) , surgery , paleontology , biology
The historical development of integrated treatment programs for locally advanced or aggressive cancers, for which the results of surgical excision or radiotherapy are unsatisfactory, is reviewed. Chemotherapy should be used first (induction chemotherapy), while tumour vasculature is intact; intra‐arterial infusion gives a greater regional effect. Central residual tumour may be eradicated by subsequent radiotherapy and/or surgery. Regional induction chemotherapy is particularly useful in treating locally advanced stage III breast cancer, locally advanced head and neck cancer, gastric cancer, and locally advanced sarcomas and melanomas of the limbs. A team approach, involving surgical and medical oncologists, radiotherapists, immunologists, and others should improve the results in these patients.