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Acute and subacute fulminant hepatic failure: the role of liver transplantation
Author(s) -
Sheil A G Ross,
McCaughan Geoffrey W,
Isai Hideya,
Hawker Felicity,
Thompson John F,
Dorney Stuart F A
Publication year - 1991
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1991.tb121308.x
Subject(s) - medicine , fulminant hepatic failure , fulminant hepatitis , liver transplantation , fulminant , hepatic encephalopathy , hepatitis , gastroenterology , transplantation , liver disease , encephalopathy , surgery , cirrhosis
Objectives To report the experience of the Australian National Liver Transplant Unit with patients with fulminant hepatic failure and to describe the role of liver transplantation. Patients: Twenty‐seven patients presented with acute or subacute fulminant hepatic failure during the period from January, 1986, to March, 1990. Twenty‐two had acute arid five had subacute fulminant hepatic failure. The causes were hepatitis B in 10 patients, presumed non‐A, non‐B {NANB) hepatitis in eight patients, drug‐induced hepatic damage in five patients, and Wilson's disease in four patients. There were 13 males and 14 females. Ages were 2–43 years (mean, 23). Twenty patients (74%) were in grade IV encephalopathy on presentation. Results Six patients (22%) began to improve soon after admission and went on to full recovery. Spontaneous recovery was more frequent in patients with drug‐induced hepatic damage (four patients [80%]) and was less frequent in those with hepatitis B (one patient [10% and NANB hepatitis (one patient [12%. The other 21 patients (78%) were considered for orthotopic liver transplantation. Eight (30%) were judged to be unsuitable and went. on to early death. Thirteen (48%).were suitable for transplantation. Of these five (19%) died before a liver donor became available and eight (30%) received liver grafts and went. on to full recovery. Overall, 14 patients (52%) survived and 13 (48%) died. Patients with Wilson's disease (four [100% were most suitable for orthotopic liver transptantatlon whereas eight (44%) of those with hepatitis B or NANB hepatitis were unsuitable. Of the eight patients receiving liver grafts one. had hepatitis B, three had NANB hepatitis and four had Wilson's disease. Five were in grade IV encephalopathy at the time of operation. The mean waiting time for transplantation was 6.4 days. Five patients received ABO blood group compatible grafts and three received ABO incompatible grafts. Of the latter group, two subsequently required secondary orthotopic liver transplantation with ABO compatible grafts. All eight patients who received transplants are alive and well 3–24 months after the operation. No patient has any neurological sequelae. Conclusions Orthotopic liver transplantation is a preferred option. for patients with fulminant hepatic failure whose condition is not responding to conservative management. ABO incompatible livers transplanted in emergency circumstances may prove lifesaving either by functioning successfully or by providing time during which ABO compatible grafts become available. Despite the availability of liver transplantation, many patients with fulminant hepatic failure in Australia still die, some before hepatic transplantation can be undertaken. Early referral of patients with fulminant hepatic failure to established centres with liver transplantation programmes is required.