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Lipid and apolipoprotein levels in an Australian community
Author(s) -
Kinlay Scott,
Dobson Annette J,
Heller Richard F,
Ryan Stephen,
Dickeson John E
Publication year - 1991
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1991.tb121023.x
Subject(s) - apolipoprotein b , body mass index , medicine , cholesterol , endocrinology , obesity , alcohol consumption , high density lipoprotein , apolipoprotein a1 , alcohol , biology , biochemistry
Serum levels of total and high density lipoprotein (HDL) cholesterol and apolipoproteins Aland B were measured in over 600 men and women aged 30‐69 years who were selected at random from an Australian community. Total cholesterol and apolipoprotein Aland B levels increased with age, with this effect being most pronounced for total cholesterol and apolipoproteln B in women. Body mass index and waist‐to‐hip ratio were positively correlated with apolipoprotein B and total cholesterol levels, and negatively correlated with apolipoprote in A1 and HDL cholesterol levels. All lipid and apolipoprote in A1 levels increased with the quantity of alcohol consumed. After adjusting for age, body mass index and smoking, the association with alcohol was strongest for apolipoprote in A1 and HDL cholesterol levels in men (P=0.0001), and for apolipoprote in A1 levels In women (P=O.Ol). Levels of apolipoprote in Aland HDL cholesterol were lower, and of apolipoprotein B and total cholesterol were higher, in current cigarette smokers than non‐smokers, with significant associations for apolipoprote in B (P=0.004) and HDL cholesterol levels (P=0.04) In men. In general, the associations between apolipoprote in A1 levels and the other variables were weaker than those for HDLcholesterol levels, whereas the associations with apolipoprote in B levels were stronger than those for total cholesterol levels (except for alcohol consumption). Thus, obesity, alcohol consumption and cigarette smoking should be considered when interpreting apolipoprote in levels.