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Prostaglandin E 1 for the treatment of primary non‐function of the donor organ in liver transplantation
Author(s) -
Mollison Lindsay C,
Angus Peter W,
Jones Robert McL
Publication year - 1991
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1991.tb116384.x
Subject(s) - medicine , liver transplantation , prostaglandin e1 , transplantation , coagulopathy , surgery , liver disease , liver function , gastroenterology
Objective : To present a case in which acute failure of a liver graft was treated with an infusion of prostaglandin E 1 (PGE 1 ). Clinical features : A nine‐year‐old girl underwent liver transplantation for Wilson's disease. Her course was complicated by primary non‐function of the graft as evidenced by poor bite production, rising bilirubin and liver enzyme levels and a severe coagulopathy. Intervention and outcome : PGE 1 was infused and there was recovery of graft function. The need for urgent re‐transplantation was avoided. Conclusions : PGE 1 may have an important role in liver transplantation considering the logistic difficulties of obtaining donor livers for urgent transplantation in Australia.