Premium
Treatment of acute organophosphate poisoning
Author(s) -
Lotti Marcello
Publication year - 1991
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1991.tb112852.x
Subject(s) - pralidoxime , gastric lavage , organophosphate poisoning , atropine , vomiting , organophosphate , medicine , diazepam , pharmacology , anesthesia , pesticide , biology , agronomy
The biochemistry and pharmacology of poisoning by organophosphorus esters and carbamates are outlined and methods of diagnosis and treatment are discussed. Treatment consists of reduction of exposure by decontamination, induction of vomiting or gastric lavage; pharmacological treatment with atropine and oximes (pralidoxime and obidoxime); and supportive treatment with artificial respiration and centrally acting drugs such as diazepam. The sequence of treatment depends solely on the severity of poisoning.