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Prothrombinex‐induced thrombosis and its management with regional plasminogen activator in hepatic failure
Author(s) -
Anderson Brian J,
Keeley Steven R,
Johnson Neil D
Publication year - 1990
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1990.tb136946.x
Subject(s) - fulminant hepatic failure , bleeding diathesis , medicine , thrombolysis , disseminated intravascular coagulation , clotting factor , fibrinolysis , hepatic dysfunction , coagulopathy , plasminogen activator , thrombosis , platelet , myocardial infarction , transplantation , liver transplantation
Fulminant hepatic failure causes a bleeding diathesis as a result of impaired synthesis of hepatic clotting factors, thrombocytopenia, fibrinolysis and disseminated intravascular coagulation. Administration of clotting factor concentrates can cause thrombosis in patients with acute hepatic failure. Regional infusion of recombinant tissue‐type plasminogen activator may be used to induce local thrombolysis. A case report of a five‐year‐old child is presented and the literature is reviewed.