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Lipids and lipoproteins in patients undergoing coronary‐artery surgery
Author(s) -
Billington Timothy,
Janus Edward D.,
Sinclair Hilary C.
Publication year - 1989
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1989.tb136489.x
Subject(s) - triglyceride , medicine , cholesterol , coronary artery disease , artery , high density lipoprotein , cardiology , lipoprotein , endocrinology , gastroenterology , surgery
Fasting blood samples were obtained from 290 patients who were undergoing elective coronary‐artery graft procedures, and cholesterol, triglyceride and high‐density lipoprotein cholesterol levels were measured. The 1983 National Heart Foundation of Australia's Risk Factor Prevalence Study was used as a source of age‐ and sex‐matched “control” data. Of these patients, 80% had cholesterol levels of greater than 5.5 mmol/L; in 55% of patients, the level exceeded 6.5 mmol/L Only 4% of patients who received a graft showed hypertriglyceridaemia alone (triglyceride level, greater than 2 mmol/L). Combined hyperlipidaemia (cholesterol level, greater than 5.5 mmol/L and triglyceride level, greater than 2.0 mmol/L) was present in 52% of subjects. Low‐density lipoprotein cholesterol levels exceeded 3.5 mmol/L in 69% of men and in 71% of women. In terms of five 10‐year age intervals, mean plasma triglyceride and cholesterol levels were elevated significantly in patients who had undergone a coronary‐artery grafting procedure compared with those of subjects in the National Heart Foundation study. The mean high‐density lipoprotein cholesterol levels were markedly‐lower compared with those of the subjects in the National Heart Foundation study. Of those patients whose plasma cholesterol levels were less than 5.5 mmol/L, 97% of patients had high‐density lipoprotein cholesterol levels that were less than the mean level for subjects in the National Heart Foundation study. Thus, a very‐high proportion of patients who underwent coronary‐artery bypass surgery had lipid abnormalities which required intervention postoperatively.