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Primary dapsone chemoprophylaxis for Pneumocystis carinii pneumonia in immunocompromised patients infected with the human immunodeficiency virus
Author(s) -
Lucas C. Ron,
Sandland A. Murray,
Mijch Anne,
Simpson Judy M.
Publication year - 1989
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1989.tb128450.x
Subject(s) - chemoprophylaxis , pneumocystis carinii , dapsone , pneumonia , medicine , immunology , virology , opportunistic infection , immunosuppression , virus , viral disease , pneumocystis jirovecii
During a 12‐month period from August 1, 1986 to July 31,1987, a study of primary chemoprophylaxis with dapsone for Pneumocystis carinii pneumonia was undertaken in immunodeficient patients who were infected with the human immunodeficiency virus. One attack of P. carinii pneumonia occurred among 16 patients who received chemoprophylaxis immediately that a T‐helper (CD4) lymphocyte count of less than 0.2 times 10 9 /L was recorded compared with 16 attacks in the historical control group of 46 similar patients who did not receive chemoprophylaxis (log‐rank test, χ 2 = 3.72; P = 0.05).