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How accurately does the Reflotron dry‐chemistry system measure plasma total cholesterol levels when used as a community‐screening device?
Author(s) -
Phillips Seren,
Walker Sheila F.,
Wyndham Lindsay,
Shaw John
Publication year - 1988
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1988.tb120533.x
Subject(s) - reproducibility , medicine , significant difference , cholesterol , chemistry , endocrinology , chromatography
This study compared the measurements of total cholesterol levels by means of a Reflotron dry‐chemistry system and a standard laboratory method with the Hitachi 705 analyser. Simultaneous blood samples were collected by finger‐prick and by venepuncture from 80 volunteers. The ranges of total cholesterol levels were 3.38‐8.45 mmol/L (Reflotron) and 3.59‐8.83 mmol/L (Hitachi). The mean (± standard deviation [SDD difference between the two methods was 0.22 ± 0.30 mmol/L. All the subjects provided a second finger‐prick sample of blood on the next day to assess the reproducibility of the Reflotron system. The mean (±SD) cholesterol levels that were obtained by the Reflotron method on Day 1 and Day 2 were 5.38±1.17 mmol/L and 5.30±1.14 mmol/L, respectively. These results did not differ significantly (mean difference, 0.079 mmol/L; standard error, 0.045 mmol/L). Provided that the operator is trained appropriately, the Reflotron system gives rapid, accurate and reproducible results.