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Campylobacter jejuni/Campylobacter coli ‐associated Guillain‐Barré syndrome
Author(s) -
Speed Bryan R.,
Kaldor Jakov,
Watson Janette,
NewtonJohn Hugh,
Tee Wee,
Noonan Denise,
Dwyer Brian W.
Publication year - 1987
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1987.tb133228.x
Subject(s) - campylobacter jejuni , campylobacter , serology , campylobacter coli , enteritis , guillain barre syndrome , microbiology and biotechnology , biology , antibody , virology , immunology , bacteria , genetics
Immunoblot (Western blot) examination of the sera of 45 patients with the Guillain‐Barré syndrome demonstrated that between three and five immunoreactive bands that were characteristic of a recent Campylobacter jejuni/Campylobacter coli infection were present in 22 of these patients. The immunoblots paralleled the serological response that is found in campylobacter enteritis and confirmed the specificity of our previous enzyme‐linked immunosorbent assays (ELISAs), which indicates that antecedent C. jejuni/C. coli infection is common in patients with the Guillain‐Barré syndrome. We postulate that, under certain circumstances, demyelination is initiated by the leakage of campylobacter‐specific antibody across the blood‐nerve barrier.