Premium
Intermittent carbamazepine intoxication possibly related to altered absorption characteristics of the drug
Author(s) -
Eadie Mervyn J.,
Hooper Wayne D.
Publication year - 1987
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1987.tb120270.x
Subject(s) - carbamazepine , drug , absorption (acoustics) , pharmacokinetics , pharmacology , medicine , plasma concentration , epilepsy , psychiatry , materials science , composite material
In Australia intermittent carbamazepine intoxication that occurs around the expected time of the peak post‐dose plasma drug concentrations has been seen more frequently in recent years than in the past. Reworking of pharmacokinetic data from earlier studies of the drug suggests that, between 1977 and 1980, there was a change in the absorption profile of carbamazepine in the most widely used oral Australian preparation of the drug. The drug's absorption rate increased and its peak plasma levels occurred earlier. The reason for this altered absorption profile cannot now be traced, but it seems a possible explanation for the clinical problem that has emerged subsequently in a number of patients.