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Intravenous polyvalent human immunoglobulin in a case of life‐threatening immune thrombocytopenic purpura
Author(s) -
Mansberg Robert,
Coupland William W.
Publication year - 1987
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1987.tb120205.x
Subject(s) - thrombocytopenic purpura , medicine , antibody , platelet , immune system , immunology , purpura (gastropod) , corticosteroid , immunoglobulin g , immune thrombocytopenia , intravenous immunoglobulin therapy , gastroenterology , biology , ecology
Severe immune thrombocytopenic purpura (platelet count, less than 5 × 10 9 /L) and associated epistaxis, vaginal bleeding and melaena were treated successfully in a 16‐year‐old girl by means of intravenously‐administered polyvalent human immunoglobulin. After she had failed to respond to four days of high‐dose therapy with corticosteroid agents, a five‐day infusion of polyvalent normal human immunoglobulin at a concentration of 6% immunoglobulin was commenced concurrently in a dose of 0.4 g/kg each day. There was a rapid and sustained rise in the platelet count within 24 h, and this was maintained when corticosteroid therapy was administered by mouth.