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Relationship between hepatitis B virus DNA in blood and serological markers of hepatitis B infection
Author(s) -
Diegutis Peter S.,
Burnett Leslie,
Nightingale Brian N.,
Lowe S. Bunty,
Parsons Carolyn,
Hensley William J.,
Gallagher Neil D.,
Givney Robert C.,
Cossart Yvonne E.,
Keirnan Elizabeth,
Williams Gerry,
McCaughan Geoffrey,
Freiman John,
Britton Warwick
Publication year - 1986
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1986.tb115918.x
Subject(s) - hbsag , virology , hepatitis b virus , serology , antibody , antigen , hepatitis b , immunology , virus , hepatitis , medicine , liver disease , dna , biology , gastroenterology , genetics
The hepatitis B virus (HBV) DNA dot‐hybridization assay has been introduced into clinical practice in Australia and its behaviour compared with that of the classic markers of HBV infection. A good correlation exists between the presence of HBV DNA and that of hepatitis B e antigen but the degree of dissociation between HBV DNA and the e:anti‐e system was smaller than earlier studies would suggest. Patients who are seronegative for hepatitis B surface antigen (HBsAg), whether they possess anti‐HBs, anti‐HBc (antibody to the core antigen), or neither antibody, gave uniformly negative results for the presence of HBV DNA. These results are different from those that were obtained from earlier studies of patients with chronic liver disease.