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Macrodantin: a cautionary tale
Author(s) -
Davey Richard
Publication year - 1986
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1986.tb113880.x
Subject(s) - dyscrasia , nitrofurantoin , medicine , peripheral neuropathy , gastrointestinal tract , urinary system , adverse effect , antimicrobial , prophylactic treatment , peripheral blood , intensive care medicine , gastroenterology , immunology , dermatology , antibiotics , biology , microbiology and biotechnology , endocrinology , plasma cell , ciprofloxacin , multiple myeloma , diabetes mellitus
Nitrofurantoin, one of the antimicrobial agents which should be chosen for the prophylactic treatment of recurrent urinary tract infection, may be prescribed in the conventional form or, alternatively, as macrocrystals. The latter form (Macrodantin) is reported to engender less gastrointestinal intolerance but it can produce the same adverse effects as the conventional form — liver damage, acute and chronic pulmonary reactions, peripheral neuropathy, blood dyscrasias and allergic reactions — and does so just as rapidly and floridly; one such case is reported here.