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Vincristine neurotoxicity in Charcot‐Marie‐Tooth syndrome
Author(s) -
Griffiths James D.,
Stark Richard J.,
Ding Jue Chong,
Cooper Ian A.
Publication year - 1985
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1985.tb123018.x
Subject(s) - vincristine , teniposide , medicine , neurotoxicity , chemotherapy , regimen , lymphoma , oncology , surgery , toxicity , etoposide , cyclophosphamide
The case of a patient with Charcot‐Marie‐Tooth syndrome and diffuse large‐cell lymphoma, in whom a severe generalized weakness developed after the intravenous administration of vincristine (2 mg) during combination chemotherapy, is reported. Spontaneous resolution of the severe weakness occurred when teniposide was substituted for vincristine in the chemotherapy regimen.