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Plasma warfarin concentrations after a massive overdose
Author(s) -
Hackett Laurence P.,
Ilett Kenneth F.,
Chester Anne
Publication year - 1985
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1985.tb113560.x
Subject(s) - warfarin , pharmacokinetics , medicine , heparin , plasma concentration , disposition , anesthesia , plasma levels , pharmacology , atrial fibrillation , psychology , social psychology
The plasma pharmacokinetics of warfarin were studied in a patient who took an overdose of warfarin (2000 mg by mouth), together with 25 times 10 4 units of heparin administered subcutaneously. The plasma warfarin level fell rapidly (half‐life, 21.7 h), and there was no convincing evidence for dose‐dependency in its disposition.