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Airways disease: evolution, pathology, and recognition
Author(s) -
Hogg James C.,
Wright Joanne L.,
Pare Peter D.
Publication year - 1985
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1985.tb113531.x
Subject(s) - medicine , airway obstruction , lung , hyperventilation , airway , pulmonary artery , pathology , pneumonectomy , cardiology , respiratory disease , pulmonary function testing , surgery
Obstruction to airflow in the lung was studied in 150 patients who presented with coin lesions necessitating surgical resection of the lung. Pulmonary function tests were performed before surgery, and the structure of the lung or lobe was analysed by means of morphometric techniques. The evolution of obstructive airways disease appeared to be based on a progressive chronic inflammatory reaction in the respiratory and membranous bronchioles. This led to progressive airway obstruction and was associated with destruction of the lung surface. The early pulmonary vascular problems appeared to be related to progressive airways obstruction that may have increased pulmonary artery pressure by causing alveolar pressure to increase more than pleural pressure during the hyperventilation of exercise.