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Cimetidine‐theophylline interaction in patients with chronic obstructive airways disease
Author(s) -
Roberts Roderick K.,
Grice Jeffrey,
McGuffie Christine
Publication year - 1984
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1984.tb104037.x
Subject(s) - theophylline , cimetidine , medicine , bronchodilator , asthma , anesthesia , pulmonary disease
The effect of cimetidine on the elimination of theophylline was studied in six patients with chronic obstructive airways disease, who were receiving maintenance therapy with theophylline. The administration of cimetidine resulted in a decrease of 25% in the interdose clearance of theophylline, which led to an increase in “steady‐state” theophylline levels in five of the patients. Prescribes should be aware of this potential interaction and reduce theophylline dosage where appropriate.