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Neuroleptic malignant syndrome
Author(s) -
Knezevic Wally,
Mastaglia Frank L.,
Lefroy Richard B.,
Fisher Anthony
Publication year - 1984
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1984.tb103843.x
Subject(s) - neuroleptic malignant syndrome , haloperidol , fluphenazine , myoclonus , levodopa , medicine , pediatrics , psychiatry , disease , parkinson's disease , dopamine
Three cases of the neuroleptic malignant syndrome, which complicated treatment with haloperidol, fluphenazine and, in one case, with several drugs, are described. All three patients recovered and, in two, levodopa appeared to modify the course of the condition. In one patient, myoclonus was present and has persisted. The pharmacological mechanisms involved in this syndrome are discussed.