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Recurrent agranulocytosis induced by two different antithyroid agents
Author(s) -
Chen Baruch,
Lang Ruth,
Jutrin Yitzhak,
Ravid Mordechai
Publication year - 1983
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1983.tb142086.x
Subject(s) - propylthiouracil , antithyroid drugs , medicine , antithyroid agent , methimazole , pediatrics , graves' disease , disease , thyroid
A 45‐year‐old woman with thyrotoxicosis developed agranulocytosis after treatment with propylthiouracil. When the thyrotoxicosis recurred, accompanied by a severe psychotic reaction, administration of antithyroid medication was recommenced. The patient was given methimazole instead of propylthiouracil but, 10 weeks later, agranulocytosis again occurred. This is, to the best of our knowledge, the first report of a case in which agranulocytosis followed treatment with both propylthiouracil and methimazole in the same patient.