Premium
Cellular toxicity of urinary catheters
Author(s) -
Graham David T.,
Mark Gerda E.,
Pomeroy Alan R.
Publication year - 1983
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1983.tb136165.x
Subject(s) - toxicity , urinary system , implant , medicine , pharmacology , surgery
The cellular compatibility of each of several brands of urinary catheters available on the Australian market was measured by means of cellculture methods, a rabbit intramuscular implant test, and the traditional mouse systemic toxicity test. Good agreement was obtained between the in‐vitro tests and the rabbit implant tests (although the cellculture tests were simpler, more rapid, more sensitive, and quantitative). The mouse systemic toxicity test was insensitive, and detected no toxic samples. The cellculture and rabbit‐implant test results indicated that some urinary catheters can release substances harmful to mammalian cells. Such substances may contribute to the clinical reactions of urethritis and strictures after urethral catheterization.